Application of Caco-2 Cell Line in Herb-Drug Interaction Studies: Current Approaches and Challenges
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چکیده
منابع مشابه
Application of Caco-2 cell line in herb-drug interaction studies: current approaches and challenges.
The Caco-2 model is employed in pre-clinical investigations to predict the likely gastrointestinal permeability of drugs because it expresses cytochrome P450 enzymes, transporters, microvilli and enterocytes of identical characteristics to the human small intestine. The FDA recommends this model as integral component of the Biopharmaceutics Classification System (BCS). Most dedicated laboratori...
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ژورنال
عنوان ژورنال: Journal of Pharmacy & Pharmaceutical Sciences
سال: 2014
ISSN: 1482-1826,1482-1826
DOI: 10.18433/j30k63